Human JOSD1 Recombinant Protein (RPPB3771)
- SKU:
- RPPB3771
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15040
Description
| Product Name: | Human JOSD1 Recombinant Protein |
| Product Code: | RPPB3771 |
| Size: | 20µg |
| Species: | Human |
| Target: | JOSD1 |
| Synonyms: | Josephin-1, Josephin domain-containing 1, JOSD1, JSPH1, KIAA0063, dJ508I15.2. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | JOSD1 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 40% glycerol, 5mM DTT and 2mM EDTA. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMSCVPWK GDKAKSESLE LPQAAPPQIY HEKQRRELCA LHALNNVFQD SNAFTRDTLQ EIFQRLSPNT MVTPHKKSML GNGNYDVNVI MAALQTKGYE AVWWDKRRDV GVIALTNVMG FIMNLPSSLC WGPLKLPLKR QHWICVREVG GAYYNLDSKL KMPEWIGGES ELRKFLKHHL RGKNCELLLV VPEEVEAHQS WRTDV |
Josephin-1 (JOSD1) has minimal protease activity towards poly-ubiquitin chains (in vitro). JOSD1 functions as a deubiquitinating enzyme. Ubiquitin-binding sites in the Josephin domain are a factor in ubiquitin chain binding and cleavage.
JOSD1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 225 amino acids (1-202 a.a.) and having a molecular mass of 25.6kDa.JOSD1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | JOSD1: Has low protease activity towards poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme. |
| UniProt Protein Details: | Protein type:EC 3.4.19.12 Chromosomal Location of Human Ortholog: 22q13.1 Cellular Component: cytosol; membrane Molecular Function:protein binding; ubiquitin-specific protease activity Biological Process: protein deubiquitination |
| UniProt Code: | Q15040 |
| NCBI GenInfo Identifier: | 3123051 |
| NCBI Gene ID: | 9929 |
| NCBI Accession: | Q15040.1 |
| UniProt Secondary Accession: | Q15040,A8K712, |
| UniProt Related Accession: | Q15040 |
| Molecular Weight: | 23kDa |
| NCBI Full Name: | Josephin-1 |
| NCBI Synonym Full Names: | Josephin domain containing 1 |
| NCBI Official Symbol: | JOSD1�� |
| NCBI Official Synonym Symbols: | dJ508I15.2�� |
| NCBI Protein Information: | josephin-1 |
| UniProt Protein Name: | Josephin-1 |
| UniProt Synonym Protein Names: | Josephin domain-containing protein 1 |
| Protein Family: | Josephin |
| UniProt Gene Name: | JOSD1�� |
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