Growth Factors & Cytokines Recombinant Proteins
Human Interleukin5/IL5 Recombinant Protein (RPES1731)
- SKU:
- RPES1731
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Growth Factors & Cytokines
Description
Human Interleukin5/IL5 Recombinant Protein
IL-15 (interleukin 15) is a cytokine that controls T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. It binds to the IL-2 receptor's beta and gamma chains, but not the alpha subunit. IL-15 is structurally and functionally related to IL-2. Both cytokines have overlapping subunits of receptors, allowing them to battle for and limit one other's activity. The number of CD8+ memory T cells is regulated by a balance between IL-15 and IL-2. Despite the fact that they have many overlapping immunological functions, IL-2 and IL-15 are actually quite distinct players in the immune system. IL-15 is produced by a wide range of cells, including monocytes, macrophages, and DCs. Mature Human IL-15 is a protein that has 70% amino acid sequence similarity with Mouse and Rat IL-15. Human Interleukin5/IL5 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human Interleukin5/IL5 Recombinant Protein (RPES1731) |
| Product Code: | RPES1731 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | IL-15,Interleukin 15,IL15 |
| Accession: | P40933 |
| Sequence: | Asn49-Ser162 |
| Activity: | Measured in a cell proliferation assay using CTLL?2 mouse cytotoxic T cells. The ED50 for this effect is 40-200pg/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Interleukin-15 is produced by our E.coli expression system and the target gene encoding Asn49-Ser162 is expressed. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 12.5 kDa |
| AP Mol Mass: | 12 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.0. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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