Human Interleukin3/IL3 Recombinant Protein (RPES3746)
- SKU:
- RPES3746
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human Interleukin3/IL3 Recombinant Protein
Interleukin 13 (IL-13) is a single-chain glycosylated polypeptide, which belongs to the IL-13/IL-4 family. IL-13 protein is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 exerts its effects through a multi-subunit receptor comprising the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains (IL-13 Rα1 and IL-13 Rα2). As a cytokine, IL-13 protein is critical in regulating inflammatory, immune responses and diseases. In addition, it inhibits the production of pro-inflammatory cytokines and chemokines, and thus down-regulates macrophage activity. IL-13 protein and antibody is more importantly implicated as a central mediator of immunoregulatory processes in various cell types.Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
| Product Name: | Human Interleukin3/IL3 Recombinant Protein (RPES3746) |
| Product Code: | RPES3746 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | ALRH,IL-13,P600,IL13 |
| Accession: | AAK53823.1 |
| Sequence: | Gly 21-Asn 132 |
| Fusion tag: | Fc Tag |
| Activity: | Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL13RA2 at 8 µg/ml (100 ?l/well) can bind IL13 with a linear range of 0.25-8.0 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mature form of human IL13 (AAK53823.1) (Gly 21-Asn 132) was fused with the Fc region of human IgG1 at the N-terminus. |
| Purity: | > 98 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 39 kDa |
| AP Mol Mass: | 50-55 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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