Human Interleukin2/IL2 Recombinant Protein (RPES1195)
- SKU:
- RPES1195
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human Interleukin2/IL2 Recombinant Protein
IL-12 is a heterodimeric pleiotropic cytokine composed of a 40 kDa (p40) subunit and a 35 k Da (p35) subunit. The human IL-12 and mouse IL-12 share 70% amino acid identity in their p40 and p35 subunits, respectively. IL-12 is required for the differentiation of naive T cells into Th1 cells. It's a hormone that acts on T cells and can help them grow and function. It inhibits the reduction of interferon gamma (IFN-gamma) production by T cells and natural killer (NK) cells, and it increases IL-4-mediated suppression of IFN-gamma. T cells that produce IL-12 have a coreceptor, CD30, which is associated with IL-12 activity. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 mediates enhancement of the cytotoxic activity of NK cells and CD8+ cytotoxic T lymphocytes. Human Interleukin2/IL2 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human Interleukin2/IL2 Recombinant Protein (RPES1195) |
| Product Code: | RPES1195 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | CLMF,CLMF2,IL-12A,IL-12B,IL12,IL12 p70,IMD28,IMD29,NFSK,NKSF,NKSF1,NKSF2,P35 |
| Accession: | NP_002178.2 |
| Sequence: | Arg23-Ser219&Ile23-Ser328 |
| Fusion tag: | |
| Activity: | Measured in a cell proliferation assay using antibody against CD3-activated human peripheral blood lymphocytes (PBL). The ED50 for this effect is 0.1-0.5ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Interleukin-12 is produced by our Mammalian expression system and the target gene encoding Arg23-Ser219&Ile23-Ser328 is expressed. |
| Purity: | > 90 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 22.5&34.7 kDa |
| AP Mol Mass: | 40-50 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS, pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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