Immunology Recombinant Proteins
Human Interleukin-4/IL-4 Recombinant Protein (RPES2502)
- SKU:
- RPES2502
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
Human Interleukin-4/IL-4 Recombinant Protein
Interleukin-4 (IL-4) is a pleiotropic cytokine that controls a variety of T and B cell activities, including cell growth, survival, and gene expression. T cells, mast cells, and bone marrow stromal cells all make IL-4. IL-4 modulates the differentiation of naive CD4+ T cells into helper Th2 cells; characterized by a cytokine-release profile that includes IL-4, IL-5, IL-6, and IL-13; which promotes a humoral immune response. IL-4 has a major influence on the switching of immunoglobulins to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells is linked to excessive IgE synthesis and an allergic reaction. Human Interleukin-4/IL-4 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human Interleukin-4/IL-4 Recombinant Protein (RPES2502) |
| Product Code: | RPES2502 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Interleukin-4, IL-4, B-Cell Stimulatory Factor 1, BSF-1, Binetrakin, Lymphocyte Stimulatory Factor 1, Pitrakinra, IL4 |
| Accession: | P05112 |
| Sequence: | His25-Ser153 |
| Fusion tag: | |
| Activity: | Measured in a cell proliferation assay using TF?1 human erythroleukemic cells. The ED50 for this effect is 7-27 pg/mL. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Interleukin-4 is produced by our E.coli expression system and the target gene encoding His25-Ser153 is expressed. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 15.1 kDa |
| AP Mol Mass: | 13-14 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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