Inositol monophosphatase 1 (IMPA1) is a myo-inositol monophosphate dephosphorylating enzyme that gives rise to free myo-inositol, a precursor of phosphatidylinositol, and therefore regulates intracellular cellular signalling by producing the second messengers myoinosit 1,4,5-triphosphate and diacylglycerol. IMPA1 has phosphatase activity that is reliant on magnesium and is inhibited by therapeutic lithium doses. Lithium's anti-manic and anti-depressive effects in bipolar patients may be linked to the inhibition of inositol monophosphate hydroylosis, which leads to a reduction in inositol for phosphatidylinositol synthesis. FOR IMPA1 pseudogenes may also be identified on chromosome 8q21.13. IMPA1 is a gene that has been linked to mental retardation, autosomal recessive 59, and bipolar disorder. Human IMP1/IMPA1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
Recombinant Human Inositol Monophosphatase 1 is produced by our E.coli expression system and the target gene encoding Met1-Asp277 is expressed with a 6His tag at the N-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
32.3 kDa
AP Mol Mass:
30 kDa
Formulation:
Supplied as a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.25.
Shipping:
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt, store it immediately at<-20°C.
Stability and Storage:
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
system_update_altDatasheetHuman IMP1/IMPA1 Recombinant Protein The IMPA1 gene product is responsible for the final step of biotransformation of inositol triphosphate and diacylglycerol, two secon
Human CSF2 Recombinant Protein (RPES5328)The product page for this antibody is being prepared. If you have a question please don't hesitate to get in touch!