Human IL3RA/CD123 Recombinant Protein (RPES1474)
- SKU:
- RPES1474
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human IL3RA/CD123 Recombinant Protein
CD123; also known as Interleukin-3 receptor subunit alpha; belongs to the type I cytokine receptor family. In mouse; there are two classes of high-affinity IL3 receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage-committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL-3 with low affinity. The beta subunit does not bind IL-3 by itself but is required for the high-affinity binding of IL-3 to the heterodimeric receptor complex.
| Product Name: | Human IL3RA/CD123 Recombinant Protein (RPES1474) |
| Product Code: | RPES1474 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Interleukin-3 receptor subunit alpha, IL-3 receptor subunit alpha, IL-3R subunit alpha, IL-3R-alpha, IL-3RA |
| Accession: | P26951 |
| Sequence: | Thr19-Arg305 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human IL3-RA is produced by our Mammalian expression system and the target gene encoding Thr19-Arg305 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 59.9 kDa |
| AP Mol Mass: | 80-100 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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