Cytokines Recombinant Proteins

Human IL21 Recombinant Protein (RPPB0633)

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SKU:
RPPB0633
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9HBE4
Research Area:
Cytokines

Description

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Product Name:Human IL21 Recombinant Protein
Product Code:RPPB0633
Size:5µg
Species:Human
Target:IL21
Synonyms:Interleukin-21 isoform 1, CVID11, IL-21, Za11.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:IL21 protein solution (0.25mg/ml) contains phosphate buffered saline (pH7.4) and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:ADPEFMQGQD RHMIRMRQLI DIVDQLKNYV NDLVPEFLPA PEDVETNCEW SAFSCFQKAQ LKSANTGNNE RIINVSIKKL KRKPPSTNAGRRQKHRLTCP SCDSYEKKPP KEFLERFKSL LQKMIHQHLS SRTHGSEDSH HHHHH

Interleukin-21 isoform 1 or IL21, categorized as a T helper cytokine. IL21 is part of the regulation of immune responses, haematopoiesis and cell-mediated responses. IL21 has a key role in haematopoiesis and immune responses regulation, therefore can affect lymphocyte development. Activation of T cells leads to production of the IL21. The protein has a crucial role in the viral infections persistence.�

IL21 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 145 amino acids (30-162a.a.) and having a molecular mass of 16.9kDa. (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).IL21 is expressed with a 12 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:IL21: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Belongs to the IL-15/IL-21 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cytokine; Apoptosis; Secreted, signal peptide; Secreted; Cell development/differentiation

Chromosomal Location of Human Ortholog: 4q26-q27

Molecular Function:hematopoietin/interferon-class (D200-domain) cytokine receptor binding; interleukin-2 receptor binding

Biological Process: cell maturation; positive regulation of B cell proliferation; positive regulation of cell proliferation; positive regulation of cytokine production; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of natural killer cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of tyrosine phosphorylation of Stat3 protein; tyrosine phosphorylation of Stat3 protein

Disease: Immunodeficiency, Common Variable, 11

NCBI Summary:This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:Q9HBE4
NCBI GenInfo Identifier:55976599
NCBI Gene ID:59067
NCBI Accession:Q9HBE4.2
UniProt Secondary Accession:Q9HBE4,A5J0L4,
UniProt Related Accession:Q9HBE4
Molecular Weight:16,867 Da
NCBI Full Name:Interleukin-21
NCBI Synonym Full Names:interleukin 21
NCBI Official Symbol:IL21��
NCBI Official Synonym Symbols:Za11; IL-21; CVID11��
NCBI Protein Information:interleukin-21
UniProt Protein Name:Interleukin-21
UniProt Synonym Protein Names:Za11
Protein Family:Interleukin
UniProt Gene Name:IL21��
UniProt Entry Name:IL21_HUMAN
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