Human IL17RA Recombinant Protein (RPES1394)
- SKU:
- RPES1394
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human IL17RA Recombinant Protein
Interleukin-17 receptor (IL-17R); also known as Interleukin-17 receptor A (IL-17RA) and CD217 antigen (CD217); is a cytokine receptor which binds interleukin 17. IL-17R/IL-17RA (CD217) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. IL-17R/IL-17RA (CD217) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor IL-17RA play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors; this receptor likely has a multimeric structure. Defects in IL-17R/IL-17RA (CD217) are the cause of familial candidiasis type 5 (CANDF5). CANDF5 is a rare disorder with altered immune responses and impaired clearance of fungal infections; selective against Candida. It is characterized by persistent and/or recurrent infections of the skin; nails and mucous membranes caused by organisms of the genus Candida; mainly Candida albicans.
| Product Name: | Human IL17RA Recombinant Protein (RPES1394) |
| Product Code: | RPES1394 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | CANDF5,CD217,CDw217,hIL-17R,IL-17RA,IL17R |
| Accession: | NP_055154.3 |
| Sequence: | Met 1-Trp 320 |
| Fusion tag: | C-His |
| Activity: | 1. Measured by its binding ability in a functional ELISA. Immobilized recombinant human IL17A at 2 µg/ml (100 ?l/well) can bind biotinylated human IL17RA with a linear range of 1.28-32 ng/ml.2. Measured by its ability to inhibit IL-17-induced IL-6 secretion by HFF human foreskin fibroblast cells. The ED50 for this effect is typically 0.03-0.12 µg/mL. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain of human IL17RA (NP_055154.3) (Met 1-Trp 320) was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 97 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 35 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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