Cytokines Recombinant Proteins
Human IL10RA Recombinant Protein (RPPB0558)
- SKU:
- RPPB0558
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q13651
- Research Area:
- Cytokines
Description
| Product Name: | Human IL10RA Recombinant Protein |
| Product Code: | RPPB0558 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL10RA |
| Synonyms: | Interleukin 10 Receptor, Alpha, IL10R, Interleukin-10 Receptor Subunit 1, IL-10 Receptor Subunit Alpha, IL-10R Subunit Alpha, IL-10R Subunit 1, CDW210A, IL-10R1, IL-10RA, Interleukin-10 Receptor Subunit Alpha, Interleukin-10 Receptor Alpha Chain, CD210 Antigen, HIL-10R, CD210a, CD210, IBD28, IL10RA. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The IL10RA solution (0.2mg/ml) contains 20% Glycerol and Phosphate-Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | HGTELPSPPS VWFEAEFFHH ILHWTPIPNQ SESTCYEVAL LRYGIESWNS ISNCSQTLSY DLTAVTLDLY HSNGYRARVR AVDGSRHSNW TVTNTRFSVD EVTLTVGSVN LEIHNGFILG KIQLPRPKMA PANDTYESIF SHFREYEIAI RKVPGNFTFT HKKVKHENFS CVQVKPSVAS RSNKGMWSKE ECISLTRQYF TVTNHHHHHH |
| Biological Activity: | Determined by its ability to inhibit proliferation using MC/9 mouse mast cells. ED50 for this effect is ? 300 ng/ml with Human IL-10. |
Interleukin 10 receptor, alpha subunit or CDW210A, is a part of the IL-10 receptor. This protein is encoded by the IL10RA gene in humans. IL10RA is a receptor for IL-10 (interleukin 10), it is part of the interferon receptors family. This protein is responsible for the inhibition of interferon receptors synthesis by taking part in the immunosuppressive signal of interleukin 10. Among its other roles are the insulin receptor substrate-2/PI 3-kinase/AKT pathway and phosphorylation of JAK1 and TYK2 kinases.
IL10RA Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 220 amino acids (22-235 aa) and having a molecular mass of 25.2kDa.IL10RA is fused to a 6 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, cytokine Chromosomal Location of Human Ortholog: 11q23 Cellular Component: integral to membrane; plasma membrane Molecular Function:interleukin-10 binding; interleukin-10 receptor activity; protein binding; receptor activity; signal transducer activity Biological Process: cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide Disease: Inflammatory Bowel Disease 28, Autosomal Recessive |
| NCBI Summary: | The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009] |
| UniProt Code: | Q13651 |
| NCBI GenInfo Identifier: | 322510034 |
| NCBI Gene ID: | 3587 |
| NCBI Accession: | Q13651.2 |
| UniProt Secondary Accession: | Q13651,A8K6I0, B0YJ27, |
| UniProt Related Accession: | Q13651 |
| Molecular Weight: | |
| NCBI Full Name: | Interleukin-10 receptor subunit alpha |
| NCBI Synonym Full Names: | interleukin 10 receptor subunit alpha |
| NCBI Official Symbol: | IL10RA�� |
| NCBI Official Synonym Symbols: | CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1�� |
| NCBI Protein Information: | interleukin-10 receptor subunit alpha |
| UniProt Protein Name: | Interleukin-10 receptor subunit alpha |
| UniProt Synonym Protein Names: | CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD_antigen: CD210 |
| Protein Family: | Interleukin-10 receptor |
| UniProt Gene Name: | IL10RA�� |
| UniProt Entry Name: | I10R1_HUMAN |
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