Cytokines Recombinant Proteins

Human IL10RA Recombinant Protein (RPPB0557)

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SKU:
RPPB0557
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q13651
Research Area:
Cytokines

Description

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Product Name:Human IL10RA Recombinant Protein
Product Code:RPPB0557
Size:10µg
Species:Human
Target:IL10RA
Synonyms:Interleukin 10 Receptor, Alpha, IL10R, Interleukin-10 Receptor Subunit 1, IL-10 Receptor Subunit Alpha, IL-10R Subunit Alpha, IL-10R Subunit 1, CDW210A, IL-10R1, IL-10RA, Interleukin-10 Receptor Subunit Alpha, Interleukin-10 Receptor Alpha Chain, CD210 Antigen, HIL-10R, CD210a, CD210, IBD28, IL10RA.
Source:Sf9 Insect cells
Physical Appearance:Sterile filtered colorless solution.
Formulation:The IL10RA protein solution (0.2mg/ml) containing Phosphate buffered saline (pH7.4) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:HGTELPSPPS VWFEAEFFHH ILHWTPIPNQ SESTCYEVAL LRYGIESWNS ISNCSQTLSY DLTAVTLDLY HSNGYRARVR AVDGSRHSNW TVTNTRFSVD EVTLTVGSVN LEIHNGFILG KIQLPRPKMA PANDTYESIF SHFREYEIAI RKVPGNFTFT HKKVKHENFS LLTSGEVGEF CVQVKPSVAS RSNKGMWSKE ECISLTRQYF TVTNHHHHHH

IL10 is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.

IL10RA Human Recombinant produced in�Sf9 Baculovirus cells is a single, non-glycosylated, polypeptide chain containing 220 amino acids (22-235 a.a.) and having a molecular mass of 25.2kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions).IL10RA is fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:IL10RA: a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: integral to membrane; plasma membrane

Molecular Function:interleukin-10 binding; interleukin-10 receptor activity; protein binding; receptor activity; signal transducer activity

Biological Process: cytokine and chemokine mediated signaling pathway; response to lipopolysaccharide

Disease: Inflammatory Bowel Disease 28, Autosomal Recessive

NCBI Summary:The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
UniProt Code:Q13651
NCBI GenInfo Identifier:322510034
NCBI Gene ID:3587
NCBI Accession:Q13651.2
UniProt Secondary Accession:Q13651,A8K6I0, B0YJ27,
UniProt Related Accession:Q13651
Molecular Weight:
NCBI Full Name:Interleukin-10 receptor subunit alpha
NCBI Synonym Full Names:interleukin 10 receptor subunit alpha
NCBI Official Symbol:IL10RA��
NCBI Official Synonym Symbols:CD210; IL10R; CD210a; CDW210A; HIL-10R; IL-10R1��
NCBI Protein Information:interleukin-10 receptor subunit alpha
UniProt Protein Name:Interleukin-10 receptor subunit alpha
UniProt Synonym Protein Names:CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD_antigen: CD210
Protein Family:Interleukin-10 receptor
UniProt Gene Name:IL10RA��
UniProt Entry Name:I10R1_HUMAN
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