Human IL10-RA/IL0 R Alpha Recombinant Protein (RPES1770)

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SKU:
RPES1770
Product Type:
Recombinant Protein
Species:
Human

Description

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Human IL10-RA/IL0 R Alpha Recombinant Protein

Interleukin-10 Receptor alpha (IL-10R?) is a transmembrane glycoprotein member of the class II cytokine receptor family. Mature human IL-10 R? consists of a 214 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 322 aa cytoplasmic domain. Within the ECD, human IL-10 R? shares 59% aa sequence identity with mouse and rat IL-10R?. IL-10 R? is required for mediating the effects of IL-10,a critical molecule in the control of microbial infections, allergic and autoimmune inflammation, and cancer. IL-10R? is the ligand specific subunit of the IL-10 receptor complex. Noncovalent dimers of IL-10 bind to IL-10 R?, resulting in the recruitment of IL-10 Rβ. Immunosuppressive signal transduction through the IL-10 receptor complex can be inhibited by activation of TLR2, 4, or 9, enabling strengthened immune responses during infection. Polymorphisms of human IL-10 R? may limit viral immune evasion by retaining full responsiveness to human IL-10 but responding weakly to the cytomegalovirus homolog of IL10.

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