Human IL10-RA/IL0 R Alpha Recombinant Protein (RPES1770)
- SKU:
- RPES1770
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human IL10-RA/IL0 R Alpha Recombinant Protein
Interleukin-10 Receptor alpha (IL-10R?) is a transmembrane glycoprotein member of the class II cytokine receptor family. Mature human IL-10 R? consists of a 214 amino acid (aa) extracellular domain (ECD), a 21 aa transmembrane segment, and a 322 aa cytoplasmic domain. Within the ECD, human IL-10 R? shares 59% aa sequence identity with mouse and rat IL-10R?. IL-10 R? is required for mediating the effects of IL-10,a critical molecule in the control of microbial infections, allergic and autoimmune inflammation, and cancer. IL-10R? is the ligand specific subunit of the IL-10 receptor complex. Noncovalent dimers of IL-10 bind to IL-10 R?, resulting in the recruitment of IL-10 Rβ. Immunosuppressive signal transduction through the IL-10 receptor complex can be inhibited by activation of TLR2, 4, or 9, enabling strengthened immune responses during infection. Polymorphisms of human IL-10 R? may limit viral immune evasion by retaining full responsiveness to human IL-10 but responding weakly to the cytomegalovirus homolog of IL10.
| Product Name: | Human IL10-RA/IL0 R Alpha Recombinant Protein (RPES1770) |
| Product Code: | RPES1770 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Interleukin-10 receptor subunit alpha, IL-10 receptor subunit alpha, IL-10R subunit alpha, IL-10RA, CDw210a, Interleukin-10 receptor subunit 1, IL-10R subunit 1, IL-10R1, CD210, IL10RA, IL-10RA |
| Accession: | Q13651 |
| Sequence: | His22-Asn235 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human IL10-RA is produced by our Mammalian expressionsystem and the target gene encoding His22-Asn235 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 25.2 kDa |
| AP Mol Mass: | 38-59 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS,pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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