Cytokines Recombinant Proteins

Human IL 17 Recombinant Protein (RPPB0597)

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SKU:
RPPB0597
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q16552
Research Area:
Cytokines

Description

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Product Name:Human IL 17 Recombinant Protein
Product Code:RPPB0597
Size:10µg
Species:Human
Target:IL 17
Synonyms:CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8, IL17A.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:Interleukin-17 protein solution (0.171mg/ml) is supplied in 25mM Na-Acetate pH 4.8 and 50% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.

IL17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. Interleukin-17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Interleukin-17A Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 132 amino acids fragment (24-155) having a molecular weight of 19.62kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The IL-17A His is purified by proprietary chromatographic techniques.

UniProt Protein Function:IL17A: Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. Belongs to the IL-17 family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6p12

Cellular Component: extracellular space; external side of plasma membrane

Molecular Function:cytokine activity

Biological Process: cell death; cell-cell signaling; apoptosis; positive regulation of interleukin-23 production; positive regulation of osteoclast differentiation; protein amino acid glycosylation; positive regulation of transcription from RNA polymerase II promoter; immune response; inflammatory response

NCBI Summary:The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq, Jul 2008]
UniProt Code:Q16552
NCBI GenInfo Identifier:2498481
NCBI Gene ID:3605
NCBI Accession:Q16552.1
UniProt Secondary Accession:Q16552,Q5T2P0,
UniProt Related Accession:Q16552
Molecular Weight:17,504 Da
NCBI Full Name:Interleukin-17A
NCBI Synonym Full Names:interleukin 17A
NCBI Official Symbol:IL17A��
NCBI Official Synonym Symbols:IL17; CTLA8; IL-17; IL-17A��
NCBI Protein Information:interleukin-17A; CTLA-8; cytotoxic T-lymphocyte-associated antigen 8; cytotoxic T-lymphocyte-associated protein 8; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
UniProt Protein Name:Interleukin-17A
UniProt Synonym Protein Names:Cytotoxic T-lymphocyte-associated antigen 8; CTLA-8
Protein Family:Interleukin
UniProt Gene Name:IL17A��
UniProt Entry Name:IL17_HUMAN
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