Cytokines Recombinant Proteins
Human IL 11 Recombinant Protein (RPPB0561)
- SKU:
- RPPB0561
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P20809
- Research Area:
- Cytokines
Description
| Product Name: | Human IL 11 Recombinant Protein |
| Product Code: | RPPB0561 |
| Size: | 10µg |
| Species: | Human |
| Target: | IL 11 |
| Synonyms: | Interleukin-11, IL-11, Adipogenesis inhibitory factor, AGIF, Oprelvekin, IL11. |
| Source: | Pichia Pastoris |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | IL11 was Lyophilized from a 0.2 �m filtered concentrated solution of 20mM PB, pH7.2 and 2% Glycine buffer. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleukin -11 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL11 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL11 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Gly-Pro-Pro-Pro-Gly |
| Biological Activity: | The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 7TD1 was found to be less then 0.2ng-0.8ng/ml, corresponding to a Specific Activity of greater than 1,000,000 IU/ mg. |
IL11 is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). IL-11 is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells.
IL11 Human Recombinant produced in Pichia Pastoris is a single,�non-glycosylated, Polypeptide chain containing 177 amino acids (it differs from the 178 amino acid length of the native IL11 only in lack of�the N-terminal praline residue) and having a molecular mass of 19kDa.The IL11 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | IL11: Directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. Belongs to the IL-6 superfamily. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Cytokine; Cell cycle regulation; Secreted, signal peptide Chromosomal Location of Human Ortholog: 19q13.3-q13.4 Cellular Component: extracellular space; cytoplasm; extracellular region Molecular Function:growth factor activity; cytokine activity; interleukin-11 receptor binding Biological Process: fat cell differentiation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of MAPKKK cascade; cell-cell signaling; megakaryocyte differentiation; B cell differentiation; negative regulation of hormone secretion; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012] |
| UniProt Code: | P20809 |
| NCBI GenInfo Identifier: | 124294 |
| NCBI Gene ID: | 3589 |
| NCBI Accession: | P20809.1 |
| UniProt Secondary Accession: | P20809,Q96EB4, B4DQV5, |
| UniProt Related Accession: | P20809 |
| Molecular Weight: | 12,994 Da |
| NCBI Full Name: | Interleukin-11 |
| NCBI Synonym Full Names: | interleukin 11 |
| NCBI Official Symbol: | IL11�� |
| NCBI Official Synonym Symbols: | AGIF; IL-11�� |
| NCBI Protein Information: | interleukin-11; oprelvekin; adipogenesis inhibitory factor |
| UniProt Protein Name: | Interleukin-11 |
| UniProt Synonym Protein Names: | Adipogenesis inhibitory factor; AGIF; INN: Oprelvekin |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL11�� |
| UniProt Entry Name: | IL11_HUMAN |
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