Metabolism Recombinant Proteins
Human IDH1 Recombinant Protein (R132H, C-8His) (RPES2708)
- SKU:
- RPES2708
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Metabolism
Description
Human IDH1 Recombinant Protein (R132H, C-8His)
Isovalerate dehydrogenase [NADP] Cytoplasmic (IDH1) is part of the isocitrate and isopropylmalate dehydrogenases family. The protein IDH1 is a dimer that binds one magnesium or manganese ion per subunit. Metaphyseal chondromatosis with aciduria is observed in patients who have a mutation of IDH1. Glioma occurs as a result of mutations of IDH1. The enzyme IDH is involved in the regeneration of NADPH for intracellular reductions, such as conversion of 2; 4-dienoyl-CoAs to 3-enoyl-CoAs; and peroxisomal reactions that consume 2-oxoglutarate, such as alpha-hydroxylation of phytanic. Human IDH1 Recombinant Protein (R132H, C-8His) is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human IDH1 Recombinant Protein (R132H, C-8His) (RPES2708) |
| Product Code: | RPES2708 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Isocitrate Dehydrogenase [NADP] Cytoplasmic, IDH, Cytosolic NADP-Isocitrate Dehydrogenase, IDP, NADP(+)-Specific ICDH, Oxalosuccinate Decarboxylase, IDH1, PICD |
| Accession: | O75874 |
| Sequence: | Met1-Leu414(Arg132His) |
| Fusion tag: | C-8His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Isocitrate Dehydrogenase [NADP] Cytoplasmic is produced by our E.coli expression system and the target gene encoding Met1-Leu414(Arg132His) is expressed with a 8His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 48.1 kDa |
| AP Mol Mass: | 40-50 kDa |
| Formulation: | Supplied as a 0.2 µm filtered solution of 50mM Tris; 200mM NaCl; 10% glycerol; pH8.0. |
| Shipping: | This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C. |
| Stability and Storage: | Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles. |
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