Human HSPBP1 Recombinant Protein (RPPB5260)

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SKU:
RPPB5260
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NZL4

Description

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Product Name:Human HSPBP1 Recombinant Protein
Product Code:RPPB5260
Size:10µg
Species:Human
Target:HSPBP1
Synonyms:Hsp70-binding protein 1, Heat shock protein-binding protein 1, Hsp70-interacting protein 1, Hsp70-binding protein 2, Hsp70-interacting protein 2, HspBP1, HspBP2, HSPBP1, HSPBP, FES1.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:HSPBP1 solution containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 30% glycerol, 2mM EDTA and 0.1M NaCl.
Stability:HSPBP1 Human Recombinant although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MSDEGSRGSR LPLALPPASQ GCSSGGGGGG GGGSSAGGSG NSRPPRNLQG LLQMAITAGS EEPDPPPEPM SEERRQWLQE AMSAAFRGQR EEVEQMKSCL RVLSQPMPPT AGEAEQAADQ QEREGALELL ADLCENMDNA ADFCQLSGMH LLVGRYLEAG AAGLRWRAAQ LIGTCSQNVA AIQEQVLGLG ALRKLLRLLD RDACDTVRVK ALFAISCLVR EQEAGLLQFL RLDGFSVLMR AMQQQVQKLK VKSAFLLQNL LVGHPEHKGT LCSMGMVQQL VALVRTEHSP FHEHVLGALC SLVTDFPQGV RECREPELGL EELLRHRCQL LQQHEEYQEELEFCEKLLQT CFSSPADDSM DR

Hsp70-binding protein 1 (HSPBP1) is a member of a family of eukaryotic proteins identified as nucleotide exchange factors for HSP 70 that exhibit varying degrees of compartment and species specificity. HSPBP1 is localized mainly in cytoplasm and nucleus but is also found extracellularly. HSPBP1 is mostly expressed in heart and skeletal muscle .HSPBP1 binds to HSP 70, inhibits its activity and promotes dissociation of nucleotides from the HSP 70 ATPase domain. In addition, HSPBP1 inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and obstructing the ATP binding. HSPBP1 may also have a role in tumor (dys)regulation of chaperone proteins. Furthermore, HSPBP1 hinders ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

HSPBP1 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 382 amino acids (1-362 a.a.) and having a molecular mass of 41.6kDa. HSPBP1 is fused to a 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:HSPBP1: Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 19q13.42

Molecular Function:enzyme inhibitor activity; protein binding

Biological Process: protein folding; positive regulation of protein ubiquitination; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of catalytic activity

UniProt Code:Q9NZL4
NCBI GenInfo Identifier:74734730
NCBI Gene ID:23640
NCBI Accession:Q9NZL4.1
UniProt Secondary Accession:Q9NZL4,O95351, Q6ZNU5, B3KQP0, B4DG11,
UniProt Related Accession:Q9NZL4
Molecular Weight:362
NCBI Full Name:Hsp70-binding protein 1
NCBI Synonym Full Names:HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
NCBI Official Symbol:HSPBP1��
NCBI Official Synonym Symbols:FES1��
NCBI Protein Information:hsp70-binding protein 1; hsp70 interacting protein; heat shock protein-binding protein 1
UniProt Protein Name:Hsp70-binding protein 1
UniProt Synonym Protein Names:Heat shock protein-binding protein 1; Hsp70-binding protein 2; HspBP2; Hsp70-interacting protein 1; Hsp70-interacting protein 2
Protein Family:Hsp70-binding protein
UniProt Gene Name:HSPBP1��
UniProt Entry Name:HPBP1_HUMAN
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