Human HSPA6 Recombinant Protein (RPPB5247)

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SKU:
RPPB5247
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P17066

Description

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Product Name:Human HSPA6 Recombinant Protein
Product Code:RPPB5247
Size:25µg
Species:Human
Target:HSPA6
Synonyms:HSP70B, Heat shock 70 kDa protein 6, Heat shock 70 kDa protein B', HSPA6.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The HSPA6 protein solution contains 20mM Tris-HCl, pH-8, 100mM NaCl & 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MQAPRELAVG IDLGTTYSCV GVFQQGRVEI LANDQGNRTT PSYVAFTDTE RLVGDAAKSQ AALNPHNTVF DAKRLIGRKF ADTTVQSDMK HWPFRVVSEG GKPKVRVCYR GEDKTFYPEE ISSMVLSKMK ETAEAYLGQP VKHAVITVPA YFNDSQRQAT KDAGAIAGLN VLRIINEPTA AAIAYGLDRR GAGERNVLIF DLGGGTFDVS VLSIDAGVFE VKATAGDTHL GGEDFDNRLV NHFMEEFRRK HGKDLSGNKR ALRRLRTACE RAKRTLSSST QATLEIDSLF EGVDFYTSIT RARFEELCSD LFRSTLEPVE KALRDAKLDK AQIHDVVLVG GSTRIPKVQK LLQDFFNGKE LNKSINPDEA VAYGAAVQAA VLMGDKCEKV QDLLLLDVAP LSLGLETAGG VMTTLIQRNA TIPTKQTQTFTTYSDNQPGV FIQVYEGERA MTKDNNLLGR FELSGIPPAP RGVPQIEVTF DIDANGILSV TATDRSTGKA NKITITNDKG RLSKEEVERM VHEAEQYKAE DEAQRDRVAA KNSLEAHVFH VKGSLQEESL RDKIPEEDRR KMQDKCREVL AWLEHNQLAE KEEYEHQKRE LEQICRPIFS RLYGGPGVPG GSSCGTQARQ GDPSTGPIIE EVD

HSPA6 is a distinctive member of the human Hsp70 chaperone that takes part in cellular processes such as protein trafficking, folding, and prevention of aggregation. HSPA6 is strictly stress-inducible, having little or no basal expression levels in most cells. HSPA6 and HSP72 are are involved in cell survival of proteotoxic stress.

Recombinant Human HSPA6 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 663 amino acids (1-643 a.a) and having a molecular mass of 73.2kDa.HSPA6 human recombinant is fused to a 20 amino acid His Tag at N-terminus and purified by conventional chromatography techniques.

UniProt Protein Function:HSPA6: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage. Belongs to the heat shock protein 70 family.
UniProt Protein Details:

Protein type:Heat shock protein

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: centriole; cytoplasm; cytosol; signalosome

Molecular Function:ATPase activity, coupled; enzyme binding; heat shock protein binding; protein binding; unfolded protein binding

Biological Process: protein refolding; response to unfolded protein

UniProt Code:P17066
NCBI GenInfo Identifier:34978357
NCBI Gene ID:3310
NCBI Accession:P17066.2
UniProt Secondary Accession:P17066,Q1HBA8, Q8IYK7, Q9BT95,
UniProt Related Accession:P17066
Molecular Weight:71,028 Da
NCBI Full Name:Heat shock 70 kDa protein 6
NCBI Synonym Full Names:heat shock protein family A (Hsp70) member 6
NCBI Official Symbol:HSPA6��
NCBI Official Synonym Symbols:HSP70B'��
NCBI Protein Information:heat shock 70 kDa protein 6
UniProt Protein Name:Heat shock 70 kDa protein 6
UniProt Synonym Protein Names:Heat shock 70 kDa protein B'
Protein Family:Heat shock 70 kDa protein
UniProt Gene Name:HSPA6��
UniProt Entry Name:HSP76_HUMAN
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