Human HMGN3 Recombinant Protein (RPPB5893)
- SKU:
- RPPB5893
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q15651
Description
| Product Name: | Human HMGN3 Recombinant Protein |
| Product Code: | RPPB5893 |
| Size: | 20µg |
| Species: | Human |
| Target: | HMGN3 |
| Synonyms: | High Mobility Group Nucleosomal Binding Domain 3, TRIP7,TR-Interacting Protein 7, High Mobility Group Nucleosome-BindingDomain-Containing Protein 3, Thyroid Hormone Receptor Interacting Protein 7, ThyroidReceptor-Interacting Protein 7, Thyroid Hormone Receptor Interactor 7, PNAS-24,PNAS-25, TRIP-7, High mobility group nucleosome-binding domain-containingprotein 3. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | HMGN3 protein solution (0.5mg/ml) containing 20mMTris-HCl buffer (pH7.0) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMPKRKSP ENTEGKDGSK VTKQEPTRRS ARLSAKPAPP KPEPKPRKTSAKKEPGAKIS RGAKGKKEEK QEAGKEGTEN |
High Mobility Group Nucleosomal Binding Domain 3 (HMGN3), binds thyroidhormone receptor beta, however it occurs only in the presence of thyroidhormone. Thyroid hormone receptors are hormone-dependent transcription factorswhich regulate expression of a variety of particular target genes.� HMGN3 is considered to reduce the compactnessof the chromatin fiber in nucleosomes, in that way enhancing transcription fromchromatin templates.
HMGN3 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 100 amino acids (1-77 a.a) andhaving a molecular mass of 10.8 kDa.HMGN3 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | HMGN3: Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function. Belongs to the HMGN family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 6q14.1 Cellular Component: cytoplasm; nucleoplasm |
| NCBI Summary: | The protein encoded by this gene binds thyroid hormone receptor beta in the presence of thyroid hormone. The encoded protein, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is a related pseudogene on chromosome 1. [provided by RefSeq, Jan 2016] |
| UniProt Code: | Q15651 |
| NCBI GenInfo Identifier: | 23831169 |
| NCBI Gene ID: | 9324 |
| NCBI Accession: | Q15651.2 |
| UniProt Secondary Accession: | Q15651,Q5HYD3, Q7RTT0, Q969M5, Q9BZT7, B2RD37, |
| UniProt Related Accession: | Q15651 |
| Molecular Weight: | 8,378 Da |
| NCBI Full Name: | High mobility group nucleosome-binding domain-containing protein 3 |
| NCBI Synonym Full Names: | high mobility group nucleosomal binding domain 3 |
| NCBI Official Symbol: | HMGN3�� |
| NCBI Official Synonym Symbols: | TRIP7; PNAS-24; PNAS-25�� |
| NCBI Protein Information: | high mobility group nucleosome-binding domain-containing protein 3 |
| UniProt Protein Name: | High mobility group nucleosome-binding domain-containing protein 3 |
| UniProt Synonym Protein Names: | Thyroid receptor-interacting protein 7; TR-interacting protein 7; TRIP-7 |
| Protein Family: | High mobility group nucleosome-binding domain-containing protein |
| UniProt Gene Name: | HMGN3�� |
| UniProt Entry Name: | HMGN3_HUMAN |
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