Immune Checkpoint Recombinant Proteins

Human HER3 Recombinant Protein (His Tag) (HDPT0067)

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SKU:
HDPT0067
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immune Checkpoint

Description

Human HER3 Recombinant Protein (His Tag)

Description:This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
Product name:Human HER3 Recombinant Protein (His Tag)
Synonyms:HER3, ERBB3
Type:protein
Size:50 µg
Name:HER3
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:Contact Technical Support
Purity:> 95%
Purification:affinity purification
Format:Lyophilized
Conjugate:C-6×His tag
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:HER3(Ser20-Thr643)+6×His tag
Gene ID:2065
Uniprot:P21860
Molecular Weight:69.39 kDa
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