Epigenetics & Nuclear Signaling Recombinant Proteins
Human HER2/ErbB2 Recombinant Protein (RPES3675)
- SKU:
- RPES3675
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Epigenetics & Nuclear Signaling
Description
Human HER2/ErbB2 Recombinant Protein
Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein; and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development; cell proliferation and differentiation. HER2 has been reported to associate with malignancy and a poor prognosis in numerous carcinomas; including breast; prostate; ovarian; lung cancers and so on. HER2 is activated by dimerization and not activated by EGF; TGF-alpha and amphiregulin. Interaction with PTK6 increases its intrinsic kinase activity.It is heterodimer with EGFR; ERBB3 and ERBB4. HER2 associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. It implicated in transcriptional activation of CDKN1A and the function of the protein involves STAT3 and SRC. And also it involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
| Product Name: | Human HER2/ErbB2 Recombinant Protein (RPES3675) |
| Product Code: | RPES3675 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu,Tyrosine kinase-type cell surface receptor HER2, ERBB2,MLN19,NGL,TKR1,CD340,ENV,ENVW,ERVWE1,HER-2,HER-2/neu,HER2,HERV-7q,HERV-W-ENV,HERV7Q,HERVW,HERVWENV,MLN 19,TKR1 |
| Accession: | P04626 |
| Sequence: | Thr 23-Thr652 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Receptor tyrosine-protein kinase ErbB-2 is produced by our Mammalian expression system and the target gene encoding Thr23-Thr652 is expressed with a Fc tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 96.5 kDa |
| AP Mol Mass: | 125 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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