Human Hemojuvelin/HFE2 Recombinant Protein (RPES3434)
- SKU:
- RPES3434
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human Hemojuvelin/HFE2 Recombinant Protein
Hemojuvelin, also known as HFE2, is a membrane-bound and soluble protein which belongs to the repulsive guidance molecule (RGM) family. It is known that RGMs function through Neogenin, a homologue of the Netrin receptor deleted in colon cancer. In mammals, RGM family consists of three glycoproteins which have discrete expression patterns and functions (RGM-A, RGM-B, and RGM-C). Hemojuvelin is expressed in adult and fetal liver, heart, and skeletal muscle. Hemojuvelin acts as a bone morphogenetic protein (BMP) coreceptor. Enhancement of BMP signaling regulates hepcidin (HAMP) expression and iron metabolism. It plays a key role in iron metabolism. Hemojuvelin represents the cellular receptor for hepcidin. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. Defects in hemojuvelin are the cause of hemochromatosis type 2A, also known as juvenile hemochromatosis (JH).
| Product Name: | Human Hemojuvelin/HFE2 Recombinant Protein (RPES3434) |
| Product Code: | RPES3434 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | HFE2A,HJV,JH,RGMC |
| Accession: | Q6ZVN8-1 |
| Sequence: | Met 1-Ser 399 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the mature form of human HFE2 isoform a (Q6ZVN8-1) (Met 1-Ser 399) was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 40 kDa |
| AP Mol Mass: | 20, 34 and 44 kDa |
| Formulation: | Lyophilized from sterile PBS, 500mM NaCl, pH 7.0, 10% gly |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Related Products
Human RNAS2 Recombinant Protein
Human CRP Recombinant Recombinant Protein (RPPB3262)
Human TGFB1 Recombinant Recombinant Protein (RPPB0968)
Growth Factors & Cytokines Recombinant Proteins
Human Acrp30 Protein Recombinant Protein (RPPB5717)
Cytokines Recombinant Proteins
Human PIP Protein Recombinant Protein (RPPB0886)
Growth Factors & Cytokines Recombinant Proteins