Human GREM2 Recombinant Protein (RPPB5890)

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SKU:
RPPB5890
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9H772

Description

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Product Name:Human GREM2 Recombinant Protein
Product Code:RPPB5890
Size:20µg
Species:Human
Target:GREM2
Synonyms:CKTSF1B2, DAND3, PRDC, Gremlin-2, Cysteine knot superfamily 1, BMP antagonist 2, DAN domain family member 3, Protein related to DAN and cerberus, GREM2.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The GREM2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSRKNRPAG AIPSPYKDGS SNNSERWQHQ IKEVLASSQE ALVVTERKYL KSDWCKTQPL RQTVSEEGCR SRTILNRFCY GQCNSFYIPR HVKKEEESFQ SCAFCKPQRV TSVLVELECP GLDPPFRLKK IQKVKQCRCM SVNLSDSDKQ

GREM2 which is a member of the BMP (bone morphogenic protein) antagonist family takes part in regulating organogenesis, body patterning, and tissue differentiation. GREM2 is an antagonist of BMP and like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, is characterized by a C-terminal cystine knot with an 8-membered ring.

GREM2 Human Recombinant produced in E. coli is a single polypeptide chain containing 170 amino acids (22-168) and having a molecular mass of 19kDa. GREM2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GREM2: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner. Antagonized BMP4-induced suppression of progesterone production in granulosa cells. Belongs to the DAN family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q43

Cellular Component: extracellular space; extracellular region

Molecular Function:heparin binding; protein homodimerization activity; cytokine activity

Biological Process: BMP signaling pathway; embryonic body morphogenesis; cytokine and chemokine mediated signaling pathway; determination of dorsal identity

NCBI Summary:This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq, Jul 2008]
UniProt Code:Q9H772
NCBI GenInfo Identifier:71164892
NCBI Gene ID:64388
NCBI Accession:NP_071914.3
UniProt Secondary Accession:Q9H772,Q86UD9,
UniProt Related Accession:Q9H772
Molecular Weight:19,320 Da
NCBI Full Name:gremlin-2
NCBI Synonym Full Names:gremlin 2, DAN family BMP antagonist
NCBI Official Symbol:GREM2��
NCBI Official Synonym Symbols:PRDC; DAND3; CKTSF1B2��
NCBI Protein Information:gremlin-2; DAN domain family member 3; protein related to DAN and cerberus; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog
UniProt Protein Name:Gremlin-2
UniProt Synonym Protein Names:Cysteine knot superfamily 1, BMP antagonist 2; DAN domain family member 3; Protein related to DAN and cerberus
Protein Family:Gremlin
UniProt Gene Name:GREM2��
UniProt Entry Name:GREM2_HUMAN
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