Human GP9 Recombinant Protein (RPPB3632)
- SKU:
- RPPB3632
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P14770
Description
| Product Name: | Human GP9 Recombinant Protein |
| Product Code: | RPPB3632 |
| Size: | 20µg |
| Species: | Human |
| Target: | GP9 |
| Synonyms: | Platelet glycoprotein IX, GP-IX, GPIX, Glycoprotein 9, CD42a, Glycoprotein IX (Platelet). |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | GP9 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2M UREA and10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSTKDCPSP CTCRALETMG LWVDCRGHGL TALPALPART RHLLLANNSLQSVPPGAFDH LPQLQTLDVT QNPWHCDCSL TYLRLWLEDR TPEALLQVRC ASPSLAAHGP LGRLTGYQLGSCGWQLQASW VRPG |
Glycoprotein-9 (GP9) is a small membrane glycoprotein found on the surface of human platelets. GP9 forms a one to one noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex which functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein and platelet glycoprotein V. GP9 gene defects cause the Bernard-Soulier syndrome, aka giant platelet disease whose patients have unusually large platelets and have a clinical bleeding tendency.
GP9 Human Recombinant produced in E.coli is a single,non-glycosylated polypeptide chain containing 154 amino acids (17-147) andhaving a molecular mass of 16.8kDa. GP9 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GPIX: The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib. Defects in GP9 are a cause of Bernard-Soulier syndrome (BSS); also known as giant platelet disease (GPD). BSS patients have unusually large platelets and have a clinical bleeding tendency. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3q21.3 Cellular Component: integral to plasma membrane; plasma membrane Biological Process: platelet activation; blood coagulation; cell adhesion; blood coagulation, intrinsic pathway Disease: Bernard-soulier Syndrome |
| NCBI Summary: | This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq, Oct 2008] |
| UniProt Code: | P14770 |
| NCBI GenInfo Identifier: | 2822110 |
| NCBI Gene ID: | 2815 |
| NCBI Accession: | P14770.3 |
| UniProt Secondary Accession: | P14770,Q14445, Q8N1D1, Q92525, |
| UniProt Related Accession: | P14770 |
| Molecular Weight: | 177 |
| NCBI Full Name: | Platelet glycoprotein IX |
| NCBI Synonym Full Names: | glycoprotein IX (platelet) |
| NCBI Official Symbol: | GP9�� |
| NCBI Official Synonym Symbols: | GPIX; CD42a�� |
| NCBI Protein Information: | platelet glycoprotein IX; glycoprotein 9 |
| UniProt Protein Name: | Platelet glycoprotein IX |
| UniProt Synonym Protein Names: | Glycoprotein 9; CD_antigen: CD42a |
| Protein Family: | Platelet glycoprotein |
| UniProt Gene Name: | GP9�� |
| UniProt Entry Name: | GPIX_HUMAN |
Related Products
Human TGFB1 Recombinant Recombinant Protein (RPPB0968)
Growth Factors & Cytokines Recombinant Proteins
Human RNAS2 Recombinant Protein
