Cell Death Recombinant Proteins
Human GITR/TNFRSF18 Recombinant Protein (RPES2510)
- SKU:
- RPES2510
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Death
Description
Human GITR/TNFRSF18 Recombinant Protein
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA?isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1; TRAF2; and TRAF3; but not TRAF5 and TRAF6 and binds through its C-terminus to SIVA1/SIVA.It preferentially expressed in activated T lymphocytes and up-regulated in peripherical mononuclear cells after antigen stimulation/lymphocyte activation.
| Product Name: | Human GITR/TNFRSF18 Recombinant Protein (RPES2510) |
| Product Code: | RPES2510 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Tumor necrosis factor receptor superfamily member 18, TNFRSF18, Glucocorticoid-induced TNFR-related protein, CD357, TNFRSF18, AITR, GITR |
| Accession: | Q9Y5U5 |
| Sequence: | Gln26-Glu161(Thr45Ala) |
| Fusion tag: | C-mFc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant human GITR is produced by our Mammalian expression system and the target gene encoding Gln26-Glu161(Thr45Ala) is expressed with a mFc tag at the C-terminus. |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
| Mol Mass: | 41.1 kDa |
| AP Mol Mass: | 40-55 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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