Human GIP Recombinant Protein (RPPB3595)

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RPPB3595

Description

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Product Name:Human GIP Recombinant Protein
Product Code:RPPB3595
Size:10µg
Species:Human
Target:GIP
Synonyms:Gastric inhibitory polypeptide, GIP, Incretin hormone.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The GIP solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 50% glycerol 0.1M NaCl and 2mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSEKKEGHF SALPSLPVGS HAKVSSPQPR GPRYAEGTFI SDYSIAMDKI HQQDFVNWLL AQKGKKNDWK HNITQREARA LELAGQANRK EEEAVEPQSS PAKNPSDEDL LRDLLIQELL ACLLDQTNLC RLRSR

Gastric Inhibitory Polypeptide (GIP) which is a significant hormone of the enteroinsular axis has a functional profile of possible therapeutic value for type 2 diabetes. GIP is an important incretin hormone released into the circulation from endocrine K-cells of the duodenum and jejunum after ingestion of food1. GIP was evaluated for�his ability to elevate cellular cAMP production. GIP promotes plasma triglyceride clearance in response to oral fat loading.

GIP Human Recombinant produced in E. coli is a single polypeptide chain containing 155 amino acids (22-153) and having a molecular mass of 17.3kDa. GIP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GIP: Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. Belongs to the glucagon family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 17q21.3-q22

Cellular Component: extracellular space; cell soma; endoplasmic reticulum lumen; extracellular region

Molecular Function:hormone activity

Biological Process: response to drug; response to peptide hormone stimulus; adult locomotory behavior; positive regulation of insulin secretion; female pregnancy; sensory perception of pain; response to amino acid stimulus; signal transduction; response to lipid; endocrine pancreas development; response to organic cyclic substance; memory; response to starvation; response to selenium ion; cellular protein metabolic process; response to glucose stimulus; response to axon injury; regulation of insulin secretion

NCBI Summary:This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]
UniProt Code:P09681
NCBI GenInfo Identifier:121194
NCBI Gene ID:2695
NCBI Accession:P09681.1
UniProt Secondary Accession:P09681,Q4VB42, Q6NTD3,
UniProt Related Accession:P09681
Molecular Weight:153
NCBI Full Name:Gastric inhibitory polypeptide
NCBI Synonym Full Names:gastric inhibitory polypeptide
NCBI Official Symbol:GIP��
NCBI Protein Information:gastric inhibitory polypeptide; incretin hormone; glucose-dependent insulinotropic polypeptide
UniProt Protein Name:Gastric inhibitory polypeptide
UniProt Synonym Protein Names:Glucose-dependent insulinotropic polypeptide; Incretin hormone
Protein Family:Gastric inhibitory polypeptide
UniProt Gene Name:GIP��
UniProt Entry Name:GIP_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P09681
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