Human GFRA1/GDNFRA Recombinant Protein (RPES4804)

Human GFRA1/GDNFRA Recombinant Protein

Glial Cell Line-Derived Neurotrophic Factor Family Receptor ?-1 (GDNFR?1) is a glycosylphosphatidylinositol (GPI) linked cell surface protein belonging to GDNF-family receptor ? subtype which consists of at least four members. GFR?1and GFR?2 are the cognate co-receptor for the neurotrophic factor neurturin mediating the NRTN-induced autophosphorylation and activation of the RET tyrosine kinase receptor. Soluble GFR?s released enzymatically from the cell surface by phosphatidylinositol phospholipase C, as well as recombinantly produced soluble GFR?1, can also bind with high affinity to GDNF and trigger the activation of Ret tyrosine kinase. Human GFR?1 shares 93% amino acid identity with mouse GFR?1.The expression of the various GFR?s are differentially regulated in the central and peripheral nervous system, suggesting complementary roles for the GFR?s in mediating the activities of the GDNF family of neurotrophic factors.