Hormones Recombinant Proteins

Human GCGR Recombinant Protein (RPPB1279)

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SKU:
RPPB1279
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P47871
Research Area:
Hormones

Description

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Product Name:Human GCGR Recombinant Protein
Product Code:RPPB1279
Size:10µg
Species:Human
Target:GCGR
Synonyms:GL-R, GLR, Glucagon Receptor.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:GCGR filtered (0.4 �m) and lyophilized from solution in acetonitrile/0,1%TFA and 1% (w/v) trehalose.
Solubility:It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. GCGR is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after one week at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MQVMDFLFEK WKLYGDQCHH NLSLLPPPTE LVCNRTFDKY SCWPDTPANT TANISCPWYL PWHHKVQHRF VFKRCGPDGQ WVRGPRGQPW RDASQCQMDG EEIEVQKEVA KMYSSFQLEH HHHHH

Glucagon receptor is part of the glucagon receptor family which also contains GLP-1, GLP-2, GHRH and GIP receptors. GCGR regulates blood glucose levels and is mainly expressed in the pancreas, liver and kidneys. Mutations in GCGR are a cause of non-insulin-dependent diabetes mellitus.�

GCGR Human Recombinant produced in E. coli is a single, non-glycosylated polypeptide chain (a.a 27-142) containing 125 amino acids including a 9 a.a C-terminal His tag. The total molecular mass is 14.9kDa (calculated).�

UniProt Protein Function:GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function:glucagon receptor activity; guanyl-nucleotide exchange factor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; generation of precursor metabolites and energy; glucose homeostasis; regulation of blood pressure; response to nutrient; response to starvation

Disease: Diabetes Mellitus, Noninsulin-dependent

NCBI Summary:The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
UniProt Code:P47871
NCBI GenInfo Identifier:1346144
NCBI Gene ID:2642
NCBI Accession:P47871.1
UniProt Secondary Accession:P47871,Q2M3M5,
UniProt Related Accession:P47871
Molecular Weight:54,009 Da
NCBI Full Name:Glucagon receptor
NCBI Synonym Full Names:glucagon receptor
NCBI Official Symbol:GCGR��
NCBI Official Synonym Symbols:GGR; GL-R��
NCBI Protein Information:glucagon receptor
UniProt Protein Name:Glucagon receptor
Protein Family:Glucagon receptor
UniProt Gene Name:GCGR��
UniProt Entry Name:GLR_HUMAN
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