Human Galectin 9/LGALS9 Recombinant Protein (RPES4572)
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- SKU:
- RPES4572
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
system_update_altDatasheet
Human Galectin 9/LGALS9 Recombinant Protein
Galectin-9 is a cytoplasmic protein that contains two galectin domains. Galectin-9 is an S-type lectin that is over-expressed in Hodgkin's disease tissue. Galectin-9 binds galactosides and has high affinity for the Forssman pentasaccharide. Galectin-9 plays a role in thymocyte-epithelial interactions relevant to the biology of the thymus and Inhibits cell proliferation. Galectin-9 is a ligand for HAVCR2/TIM3 and induces T-helper type 1 lymphocyte (Th1) death. In addition, Galectin-9 suppresses tumor cell metastasis by interfering with the associations CD44, VCAM-1, Integrin ?4β1.
| Product Name: | Human Galectin 9/LGALS9 Recombinant Protein (RPES4572) |
| Product Code: | RPES4572 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Galectin-9, Gal-9, Ecalectin, Tumor Antigen HOM-HD-21, LGALS9 |
| Accession: | Q3B8N1-2 |
| Sequence: | Met 1-Thr323 |
| Fusion tag: | C-6His |
| Activity: | Immobilized Human Galectin 9-His at 10µg/ml(100 ?l/well) can bind Cynomolgus TIM-3-His(Cat: PKSQ050023). The ED50 of Human Galectin 9-His is 1.75 ug/ml . |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Galectin 9 is produced by our Mammalian expression system and the target gene encoding Met1-Thr323 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 36.9 kDa |
| AP Mol Mass: | 49 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS,5% Trehalose,1mM EDTA,pH7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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