Human GADD45A/DDIT Recombinant Protein (RPES3234)

Human GADD45A/DDIT Recombinant Protein

GADD45A is a member of the GADD45 Family; and has been found to associate with several cytoplasmic and nuclear factors and has been implicated in several cellular functions; including MAPK signaling; cell cycle regulation; DNA repair and genomic stability; apoptosis; and immune responses. The GADD45 Family of genes is rapidly induced by different stressors; including differentiation-inducing cytokines; and there is a large body of evidence that their cognate proteins are key players in cellular stress responses. GADD45A protein has been reported to interact with multiple important cellular proteins; including Cdc2 protein kinase; proliferating cell nuclear antigen (PCNA); p21Waf1/Cip1 protein; core histone protein and MTK/MEKK4; an up-stream activator of the JNK/SAPK pathway; indicating that GADD45A may play important roles in the control of cell cycle checkpoint; DNA repair process; and signaling transduction. GADD45A expression in response to genotoxic stress illustrates a more complex scenario; wherein transcriptional changes operate in concert with mRNA turnover and translational regulation. GADD45A was the first stress-inducible gene determined to be up-regulated by p53 and is also a target for the p53 homologues; p63 and p73. The decreased GADD45A expression is also considered a survival mechanism; as cancer cells without this control can evade the apoptotic pathway leading to increased tumourigenesis. As GADD45A is an essential component of many metabolic pathways that control proliferating cancer cells; it presents itself as an emerging drug target worthy of further investigation.