Cell Death Recombinant Proteins

Human GADD45 gamma/GADD45G Recombinant Protein (RPES4530)

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SKU:
RPES4530
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Death

Description

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Human GADD45 gamma/GADD45G Recombinant Protein

Growth Arrest and DNA Damage-Inducible Protein GADD45 ? (GADD45G) is a nuclear protein which belongs to the GADD45 family. GADD45G is highly expressed in placenta. GADD45G interacts with various proteins whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. GADD45G is also involved in the regulation of growth and apoptosis. GADD45G inhibits cell growth and differentiation by androgens. The mRNA expression is down-regulated in hepatocellular carcinoma.

Product Name:Human GADD45 gamma/GADD45G Recombinant Protein (RPES4530)
Product Code:RPES4530
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Growth Arrest and DNA Damage-Inducible Protein GADD45 Gamma, Cytokine-Responsive Protein CR6, DNA Damage-Inducible Transcript 2 Protein, DDIT-2, GADD45G, CR6, DDIT2
Accession:O95257
Sequence:Met 1-Glu159
Fusion tag:N-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human Growth Arrest and DNA Damage-Inducible Protein GADD45 gamma is produced by our E.coli expression system and the target gene encoding Met1-Glu159 is expressed with a 6His tag at the N-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:19.3 kDa
AP Mol Mass:21 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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