Human FSTL1 Recombinant Protein (RPES3380)
- SKU:
- RPES3380
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human FSTL1 Recombinant Protein
Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently; we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here; we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module; a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation; in part; through BMP4 signaling.
| Product Name: | Human FSTL1 Recombinant Protein (RPES3380) |
| Product Code: | RPES3380 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | FRP,FSL1,MIR198 |
| Accession: | NP_009016.1 |
| Sequence: | Met 1-Ile 308 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human FSTL1 (NP_009016.1) precursor (Met 1-Ile 308) with a carboxy-terminal polyhistidine tag was expressed. |
| Purity: | > 98 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 34.2 kDa |
| AP Mol Mass: | 47 kDa |
| Formulation: | Lyophilized from sterile PBS; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Related Products
Human FSTL1 Recombinant Protein (RPPB0268)
Cytokines Recombinant Proteins
Human FSTL1 Recombinant Protein (RPPB0267)
Cytokines Recombinant Proteins
Human FSTL1 Recombinant Protein (RPES4279)
Human FSTL1 Recombinant Protein (RPES1213)
