Human Follistatin/FST Recombinant Protein (RPES3439)

Human Follistatin/FST Recombinant Protein

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms; FST317 and FST344 containing 317 and 344 amino acids respectively; resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families; evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues; including brain; adrenal; bone marrow; and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin; the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin; it is imperative to determine the nature of the activin/follistatin binding complex.