Human FGG Recombinant Protein (RPPB3537)

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SKU:
RPPB3537
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P02679

Description

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Product Name:Human FGG Recombinant Protein
Product Code:RPPB3537
Size:10µg
Species:Human
Target:FGG
Synonyms:Fibrinogen gamma chain isoform gamma-A, Fibrinogen gammachain, PRO2061.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:FGG protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSYVATRDN CCILDERFGS YCPTTCGIAD FLSTYQTKVD KDLQSLEDILHQVENKTSEV KQLIKAIQLT YNPDESSKPN MIDAATLKSR KMLEEIMKYE ASILTHDSSI RYLQEIYNSNNQKIVNLKEK VAQLEAQCQE PCKDTVQIHD ITGKDCQDIA NKGAKQSGLY FIKPLKANQQ FLVYCEIDGS GNGWTVFQKRLDGSVDFKKN WIQYKEGFGH LSPTGTTEFW LGNEKIHLIS TQSAIPYALR VELEDWNGRT STADYAMFKVGPEADKYRLT YAYFAGGDAG DAFDGFDFGD DPSDKFFTSH NGMQFSTWDN DNDKFEGNCA EQDGSGWWMN KCHAGHLNGVYYQGGTYSKA STPNGYDNGI IWATWKTRWY SMKKTTMKII PFNRLTIGEG QQHHLGGAKQ AGDV

Fibrinogen gamma chain isoform gamma-A (FGG) is the gamma component of fibrinogen, which is a blood-borne glycoprotein, comprised of 3 pairs of nonidentical polypeptide chains. FGG along with fibrinogen alpha (FGA) and fibrinogen beta (FGB) polymerizes to form an insoluble fibrin matrix. Following vascular injury, FGG is cleaved by thrombin to create fibrin, which is the most abundant component of blood clots. FGG functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Moreover, different cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, exhibit vasoconstrictor and chemotactic activities, and are mitogens for a number of cell types. Maternal fibrinogen is vital for successful pregnancy. FGG gene mutations lead to some disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Fibrin accumulation is also linked with infection, where it protects against IFNG-mediated hemorrhage.

FGG Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 434 amino acids (27-437 a.a) and having a molecular mass of 48.9kDa.FGG is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:FGG: Fibrinogen has a double Function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q28

Cellular Component: extracellular space; cell surface; fibrinogen complex; extracellular region; plasma membrane; cell cortex; external side of plasma membrane

Molecular Function:protein binding, bridging; metal ion binding; cell adhesion molecule binding; structural molecule activity; receptor binding

Biological Process: protein polymerization; platelet activation; extracellular matrix organization and biogenesis; positive regulation of heterotypic cell-cell adhesion; platelet degranulation; cellular protein complex assembly; positive regulation of protein secretion; cell-matrix adhesion; positive regulation of vasoconstriction; response to calcium ion; blood coagulation; signal transduction; positive regulation of exocytosis

Disease: Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital

NCBI Summary:The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P02679
NCBI GenInfo Identifier:20178280
NCBI Gene ID:2266
NCBI Accession:P02679.3
UniProt Secondary Accession:P02679,P04469, P04470, Q53Y18, Q96A14, Q96KJ3, Q9UC62 Q9UC63, Q9UCF3, A8K057,
UniProt Related Accession:P02679
Molecular Weight:49,497 Da
NCBI Full Name:Fibrinogen gamma chain
NCBI Synonym Full Names:fibrinogen gamma chain
NCBI Official Symbol:FGG��
NCBI Protein Information:fibrinogen gamma chain; fibrinogen, gamma polypeptide
UniProt Protein Name:Fibrinogen gamma chain
Protein Family:Fibrinogen
UniProt Gene Name:FGG��
UniProt Entry Name:FIBG_HUMAN
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