Cell Biology Recombinant Proteins
Human ESAM Recombinant Protein (RPES2995)
- SKU:
- RPES2995
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Biology
Description
Human ESAM Recombinant Protein
Endothelial Cell Adhesion Molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein member of the JAM family of immunoglobulin superfamily molecules. The 390 amino acid Human ESAM contains a 216 amino acid extracellular domain (ECD) with a V-type and a C2-type immunoglobulin (Ig) domain. ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. In addition; ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall; possibly by influencing endothelial cell contacts. ESAM-deficient mice were described with lowered angiogenic potential; and accordingly; overexpression of ESAM is closely associated with certain tumor growth and metastasis. ESAM is expressed on endothelial cells; activated platelets and megakaryocytes. The ECD of human and mouse ESAM share 69% amino acid identity.
| Product Name: | Human ESAM Recombinant Protein (RPES2995) |
| Product Code: | RPES2995 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Endothelial Cell-Selective Adhesion Molecule, ESAM |
| Accession: | Q96AP7 |
| Sequence: | Gln30-Ala247 |
| Fusion tag: | C-His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Endothelial Cell Adhesion Molecule is produced by our Mammalian expression system and the target gene encoding Gln30-Ala247 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95% as determined by reducing SDS-PAGE. |
| Mol Mass: | 24.79 kDa |
| AP Mol Mass: | 38 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB; 150mM NaCl; pH 7.2. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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