Human ESAM Recombinant Protein (RPES0676)
- SKU:
- RPES0676
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human ESAM Recombinant Protein
Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain; as well as a hydrophobic signal sequence; a single transmembrane region; and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall; possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.
| Product Name: | Human ESAM Recombinant Protein (RPES0676) |
| Product Code: | RPES0676 |
| Size: | 50µg |
| Species: | Human |
| Expressed Host: | HEK293 Cells |
| Synonyms: | W117m |
| Accession: | NP_620411.2 |
| Sequence: | Met 1-Ala 248 |
| Fusion tag: | C-Fc |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the extracellular domain (Met 1-Ala 248) of human ESAM (NP_620411.2) precursor was expressed with the fused Fc region of human IgG1 at the C-terminus. |
| Purity: | > 97 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 50.5 kDa |
| AP Mol Mass: | 65-70 kDa |
| Formulation: | Lyophilized from sterile 100mM Glycine; 10mM NaCl; 50mM Tris; pH 7.5 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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