Cell Death Recombinant Proteins
Human ERN1/IRE1 Recombinant Protein (RPES4816)
- SKU:
- RPES4816
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Death
Description
Human ERN1/IRE1 Recombinant Protein
Trypsin-3 is a secreted protease produced by the brain that belongs to the peptidase S1 family. It also goes by Trypsin III, brain trypsinogen, and Serine protease 3 and PRSS3. Trypsin-3 is secreted in the pancreas and brain. It has one peptidase S1 domain. Trypsin-3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Higher mesotrypsin activity can lead to an increased risk of chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. A trypsin-inhibitor-degrading capability identified PRSS3 as a potential CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression; which is correlated with promoter hypermethylation; in esophageal squamous cell carcinoma and gastric adenocarcinoma. Human ERN1/IRE1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human ERN1/IRE1 Recombinant Protein (RPES4816) |
| Product Code: | RPES4816 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | hIRE1p,IRE1,IRE1a,IRE1P |
| Accession: | O75460-1 |
| Sequence: | Pro 465-Leu 977 |
| Fusion tag: | |
| Activity: | 1.Kinase activity untested 2. Measured by its nuclease activity to cleave Xbp1 single stem-loop mini-substrate. |
| Endotoxin: | <1.0 EU per µg of the protein as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human ERN1 (O75460-1) (Pro 465-Leu 977) was expressed and purified with two additional amino acids (Gly & Pro ) at the N-terminus. |
| Purity: | > 80 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 58.3 kDa |
| AP Mol Mass: | 65 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris; 500mM NaCl; 10% glycerol; pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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