Cell Death Recombinant Proteins

Human ERN1/IRE1 Recombinant Protein (RPES4816)

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SKU:
RPES4816
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Death

Description

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Human ERN1/IRE1 Recombinant Protein

Trypsin-3 is a secreted protease produced by the brain that belongs to the peptidase S1 family. It also goes by Trypsin III, brain trypsinogen, and Serine protease 3 and PRSS3. Trypsin-3 is secreted in the pancreas and brain. It has one peptidase S1 domain. Trypsin-3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Higher mesotrypsin activity can lead to an increased risk of chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. A trypsin-inhibitor-degrading capability identified PRSS3 as a potential CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression; which is correlated with promoter hypermethylation; in esophageal squamous cell carcinoma and gastric adenocarcinoma. Human ERN1/IRE1 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

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