Cell Biology Recombinant Proteins
Human E-Cadherin/CDH1 Recombinant Protein (RPES4314)
- SKU:
- RPES4314
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Cell Biology
Description
Human E-Cadherin/CDH1 Recombinant Protein
E-Cadherin is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats; a transmembrane region; and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric; breast; colorectal; thyroid; and ovarian cancers. Loss of function is thought to contribute to progression in cancer by increasing proliferation; invasion; and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells; and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Also; E-Cadherin has a potent invasive suppressor role and it is a ligand for integrin alpha-E/beta-7.
| Product Name: | Human E-Cadherin/CDH1 Recombinant Protein (RPES4314) |
| Product Code: | RPES4314 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Cadherin-1, CDH1,CAM 120/80,E-cadherin, CD324,CDHE,E-cad,E-Cadherin,ECAD,LCAM,UVO,Arc-1 |
| Accession: | P12830 |
| Sequence: | Asp155-Ile707 |
| Fusion tag: | C-6His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Cadherin-1/E-Cadherin/CDH1 is produced by our Mammalian expression system and the target gene encoding Asp155-Ile707 is expressed with a 6His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 61.2 kDa |
| AP Mol Mass: | 80-90 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of PBS; pH 7.4. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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