Cell Biology Recombinant Proteins

Human E-Cadherin/CDH1 Recombinant Protein (RPES4314)

(No reviews yet) Write a Review
SKU:
RPES4314
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Biology

Description

system_update_altDatasheet

Human E-Cadherin/CDH1 Recombinant Protein

E-Cadherin is a classical member of the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats; a transmembrane region; and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric; breast; colorectal; thyroid; and ovarian cancers. Loss of function is thought to contribute to progression in cancer by increasing proliferation; invasion; and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells; and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Also; E-Cadherin has a potent invasive suppressor role and it is a ligand for integrin alpha-E/beta-7.

View AllClose

0 Reviews

View AllClose