Human DUSP14/MKP-6 Recombinant Protein (RPES2740)
- SKU:
- RPES2740
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human DUSP14/MKP-6 Recombinant Protein
Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (MAPK) / extracellular signal-regulated kinase 1 / 2 (ERK 1 / 2) pathway. DUSP14 phosphatase activity has been confirmed to be inhibited by PTP inhibitor ?. PTP inhibitor binds to the catalytic site of DUSP14. PTP inhibitor ? effectively and specifically inhibited DUSP14-mediated dephosphorylation of JNK, a member of the mitogen-activated protein kinase (MAPK) family through dephosphorylation of both the Ser / Thr and Tyr residues of MAPKs.
| Product Name: | Human DUSP14/MKP-6 Recombinant Protein (RPES2740) |
| Product Code: | RPES2740 |
| Size: | 20µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | MKP-L,MKP6 |
| Accession: | O95147 |
| Sequence: | Met 1 His 191 |
| Fusion tag: | N-His & MBP |
| Endotoxin: | Please contact us for more information. |
| Protein Construction: | A DNA sequence encoding the human DUSP14 (O95147) (Met 1 His 191) was fused with an N-terminal polyhistidine-tagged MBP tag at the N-terminus. |
| Purity: | > 88 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 65 kDa |
| AP Mol Mass: | 60 kDa |
| Formulation: | Lyophilized from sterile PBS, pH 7.5 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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