Human DR6/TNFRSF21 Recombinant Protein (RPES0911)

Human DR6/TNFRSF21 Recombinant Protein

TNFRSF21 (death receptor-6; DR6) is an orphan TNF receptor superfamily member and belongs to the death receptors subgroup. A type I transmembrane protein has four extracellular cysteine-rich motifs and a cytoplasmic death domain. N- and O-glycosylations of amino acids in its extracellular portion, as well as the extensive posttranslational modification of the transmembrane protein DR6. DR6 interacts with the adaptor protein TRADD and mediates signal transduction through its death domain; and expression of DR6 in mammalian cells induces activation of both NF-kappaB and JNK and cell apoptosis. DR6 knockout mice have enhanced CD4+ T cell proliferation and Th2 cytokine production; suggested that DR6 serves as an important regulatory molecule in T-helper cell activation; and is involved in inflammation and immune regulation. DR6 is expressed in virtually all tissues, with the highest levels seen in lymphoid organs, the heart, the brain and the pancreas. Tumor cells may express excessive levels of DR6, which is often seen in conjunction with elevated anti-apoptosis molecules. DR6 may also be involved in tumor cell survival and immune evasion; which is subject to future investigations. Human DR6/TNFRSF21 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.