Human DNAJB4 Recombinant Protein (RPPB5202)
- SKU:
- RPPB5202
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9UDY4
Description
| Product Name: | Human DNAJB4 Recombinant Protein |
| Product Code: | RPPB5202 |
| Size: | 10µg |
| Species: | Human |
| Target: | DNAJB4 |
| Synonyms: | DnaJ homolog subfamily B member 4, Heat shock 40 kDa protein 1 homolog, HSP40 homolog, Heat shock protein 40 homolog, Human liver DnaJ-like protein, DNAJB4, DNAJW, HLJ1, DjB4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | DNAJB4 protein solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.2M NaCl, 30% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMGKDYYC ILGIEKGASD EDIKKAYRKQ ALKFHPDKNK SPQAEEKFKE VAEAYEVLSD PKKREIYDQF GEEGLKGGAG GTDGQGGTFR YTFHGDPHAT FAAFFGGSNP FEIFFGRRMG GGRDSEEMEI DGDPFSAFGF SMNGYPRDRN SVGPSRLKQD PPVIHELRVS LEEIYSGCTK RMKISRKRLN ADGRSYRSED KILTIEIKKG WKEGTKITFP REGDETPNSI PADIVFIIKD KDHPKFKRDG SNIIYTAKIS LREALCGCSI NVPTLDGRNI PMSVNDIVKP GMRRRIIGYG LPFPKNPDQR GDLLIEFEVS FPDTISSSSK EVLRKHLPAS |
DnaJ (Hsp40) Homolog, Subfamily B, Member 4 (DNAJB4) is a member of the evolutionarily conserved DNAJ/HSP40 protein family. DNAJB4 subunit configuration is homodimer. DNAJB4 possibly functions as a chaperone. DNAJB4 C-terminal section interacts with the C-terminal tail of OPRM1. DNAJB4 also has an interaction with SDIM1. DNAJB4 is expressed in the heart, pancreas and skeletal muscle, and to a lesser extent in the brain, placenta and liver.
DNAJB4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 360 amino acids (1-337 a.a.) and having a molecular mass of 40kDa.DNAJB4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | DNAJB4: Probable chaperone. Homodimer. The C-terminal section interacts with the C- terminal tail of OPRM1. Interacts also with SDIM1. By heat shock. Expressed in heart, pancreas and skeletal muscle, and to a lesser extent in brain, placenta and liver. |
| UniProt Protein Details: | Protein type:Chaperone Chromosomal Location of Human Ortholog: 1p31.1 Cellular Component: cytoplasm; cytosol; nucleoplasm; plasma membrane Molecular Function:chaperone binding; protein binding; unfolded protein binding Biological Process: protein folding; response to heat; response to unfolded protein |
| NCBI Summary: | The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9UDY4 |
| NCBI GenInfo Identifier: | 8928155 |
| NCBI Gene ID: | 11080 |
| NCBI Accession: | Q9UDY4.1 |
| UniProt Secondary Accession: | Q9UDY4,Q13431, B2R824, |
| UniProt Related Accession: | Q9UDY4 |
| Molecular Weight: | 37,807 Da |
| NCBI Full Name: | DnaJ homolog subfamily B member 4 |
| NCBI Synonym Full Names: | DnaJ heat shock protein family (Hsp40) member B4 |
| NCBI Official Symbol: | DNAJB4�� |
| NCBI Official Synonym Symbols: | DjB4; HLJ1; DNAJW�� |
| NCBI Protein Information: | dnaJ homolog subfamily B member 4 |
| UniProt Protein Name: | DnaJ homolog subfamily B member 4 |
| UniProt Synonym Protein Names: | Heat shock 40 kDa protein 1 homolog; HSP40 homolog; Heat shock protein 40 homolog; Human liver DnaJ-like protein |
| Protein Family: | DnaJ homolog subfamily |
| UniProt Gene Name: | DNAJB4�� |
| UniProt Entry Name: | DNJB4_HUMAN |
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