Growth Factors & Cytokines Recombinant Proteins

Human DKK1/Dkk Recombinant Protein (RPES3093)

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SKU:
RPES3093

Description

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Human DKK1/Dkk Recombinant Protein

Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Product Name:Human DKK1/Dkk Recombinant Protein (RPES3093)
Product Code:RPES3093
Size:10µg
Species:Human
Expressed Host:Human Cells
Synonyms:Dickkopf-related protein 1,Dickkopf-1,Dkk-1,SK
Accession:O94907
Sequence:Thr32-His266
Fusion tag:N-His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human DKK1 is produced by our Mammalian expression system and the target gene encoding Thr32-His266 is expressed with a 8His tag at the N-terminus.
Purity:> 95% as determined by reducing SDS-PAGE.
Mol Mass:27 kDa
AP Mol Mass:42-47 kDa
Formulation:Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Research Area:
Growth Factors & Cytokines
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