Human Dickkopf-Related Recombinant Protein 1/DKK-1 (C-Fc) (RPES6371)

Name: Human Dickkopf-Related Recombinant Protein 1/DKK-1 (C-Fc) (RPES6371)
SKU: RPES6371
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Product Name:	Human Dickkopf-Related Recombinant Protein 1/DKK-1 (C-Fc)
Product Code:	RPES6371
Size:	10µg
Species:	Human
Expression Host:	HEK293 Cells
Synonyms:	Dickkopf-related protein 1, Dickkopf-1, Dkk-1

Mol Mass:	52.7 kDa
AP Mol Mass:	60-80 kDa
Tag:	C-Fc
Purity:	> 95 % as determined by reducing SDS-PAGE.
Endotoxin Level:	< 1.0 EU per μg of the protein as determined by the LAL method.
Bio Activity:	Testing in progress

Sequence:	Thr32-His266
Accession:	O94907
Storage:	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Shipping:	This product is provided as lyophilized powder which is shipped with ice packs.
Formulation:	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Reconstitution:	Please refer to the printed manual for detailed information.
Background:	Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.