Human Decorin Recombinant Protein (RPES3173)

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SKU:
RPES3173
Product Type:
Recombinant Protein
Species:
Human

Description

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Human Decorin Recombinant Protein

Decorin is a secreted chondroitin/dermatan sulfate proteoglycan in the family of small leucine-rich proteoglycans (SLRPs). SLRP family members are characterized by N-terminal and C-terminal cysteine-rich regions which flank the central region containing 10-12 tandem leucine-rich repeats (LRR). The human Decorin cDNA encodes a 359 amino acid (aa) precursor that includes a 16 aa signal sequence and a 14 aa propeptide. Alternate splicing of human Decorin generates five isoforms with variable length deletions. Decorin is an N-glycosylated protein that also carries a variablysized hybrid chondroitin/dermatan sulfate chain at Ser34. Decorin regulates assembly of the extracellular collagen matrix and the bioactivity of the matrix associated growth factors FGF2;GDF8/Myostatin; TGFβ;and WISP1. It also binds and activates EGF R; ErbB4; and IGFI-R. In vivo; Decorin promotes myoblast differentiation; supports angiogenesis; and inhibits tumor progression.

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