Human CTLA4/CD152 Recombinant Protein (RPES3194)

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SKU:
RPES3194
Product Type:
Recombinant Protein
Species:
Human

Description

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Human CTLA4/CD152 Recombinant Protein

Cytotoxic T-lymphocyte protein 4; also known as CTLA4 and CD152; is a single-pass type I membrane protein and a member of the immunoglobulin superfamily. It is the second member of the CD28 receptor family. The ligands or counterreceptors for these two proteins are the B7 family members; CD80 (B7-1) and CD86 (B7-2). CTLA4 transmits an inhibitory signal to T cells; whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T cells and may play an important role in their functions. CD152 or cytotoxic T lymphocyte antigen-4 (CTLA-4) is an essential receptor involved in the negative regulation of T cell activation. Because of its profound inhibitory role; CD152 has been considered a sound susceptible candidate in autoimmunity and a persuasive target for cancer immunotherapy. In particular; recent evidence suggests that CD152 is also important in the homeostasis and function of a population of suppressive cells; termed regulatory T cells (Treg).Immune CheckpointImmune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IP Antibodies   Immune Checkpoint Detection: WB AntibodiesImmune Checkpoint Proteins   CTLA4 / CD152 Immune Checkpoint ProteinsImmune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets Immunotherapy   Cancer Immunotherapy   Targeted Therapy

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