Cytokines Recombinant Proteins
Human BMP6 Recombinant Protein (RPPB0100)
- SKU:
- RPPB0100
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P22004
- Research Area:
- Cytokines
Description
| Product Name: | Human BMP6 Recombinant Protein |
| Product Code: | RPPB0100 |
| Size: | 10µg |
| Species: | Human |
| Target: | BMP6 |
| Synonyms: | Bone morphogenetic protein 6, BMP-6, VG-1-related protein, VG-1-R, VGR-1, BMP6, VGR, VGR1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | The BMP6 solution (0.25mg/ml) contains 10mM Sodium citrate buffer (pH 3.5) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHMSASSR RRQQSRNRST QSQDVARVSS ASDYNSSELK TACRKHELYV SFQDLGWQDW IIAPKGYAAN YCDGECSFPL NAHMNATNHA IVQTLVHLMN PEYVPKPCCA PTKLNAISVL YFDDNSNVIL KKYRNMVVRA CGCH |
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules, which can induce ectopic bone growth. Various BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were initially identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based upon its expression early in embryogenesis, BMP6 has a suggested role in early development. Moreover, the fact that the BMP6 is closely related to BMP5 and BMP7 leads to an assumption of possible bone inductive activity.
BMP6 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 164 amino acids (375-513) and having a molecular mass of 18kDa.BMP6 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Induces cartilage and bone formation. |
| NCBI Summary: | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016] |
| UniProt Code: | P22004 |
| NCBI GenInfo Identifier: | 115076 |
| NCBI Gene ID: | 654 |
| NCBI Accession: | P22004.1 |
| UniProt Secondary Accession: | P22004,Q5TCP3, |
| UniProt Related Accession: | P22004 |
| Molecular Weight: | 57,226 Da |
| NCBI Full Name: | Bone morphogenetic protein 6 |
| NCBI Synonym Full Names: | bone morphogenetic protein 6 |
| NCBI Official Symbol: | BMP6�� |
| NCBI Official Synonym Symbols: | VGR; VGR1�� |
| NCBI Protein Information: | bone morphogenetic protein 6 |
| UniProt Protein Name: | Bone morphogenetic protein 6 |
| UniProt Synonym Protein Names: | VG-1-related protein; VG-1-R; VGR-1 |
| Protein Family: | Bone morphogenetic protein |
| UniProt Gene Name: | BMP6�� |
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