Cytokines Recombinant Proteins

Human BMP3 Recombinant Protein (RPPB0095)

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SKU:
RPPB0095
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P12645
Research Area:
Cytokines

Description

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Product Name:Human BMP3 Recombinant Protein
Product Code:RPPB0095
Size:50µg
Species:Human
Target:BMP3
Synonyms:Bone Morphogenetic Protein 3, Osteogenin, Bone Morphogenetic Protein 3 (Osteogenic), Bone Morphogenetic Protein 3A, BMP-3A, BMP-3, Bone Morphogenetic Protein-3, BMP3A, BMP3.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:BMP-3 protein was lyophilized from a 0.2�m filtered concentrated solution in 30% Acetonitrile and 0.1% TFA.
Solubility:It is recommended to reconstitute the lyophilized BMP3 in sterile 4mM HCl not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized BMP3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BMP-3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by:�(a) Analysis by HPLC.�(b) Analysis by SDS-PAGE.
Amino Acid Sequence:QWIEPRNCAR RYLKVDFADI GWSEWIISPK SFDAYYCSGA CQFPMPKSLK PSNHATIQSI VRAVGVVPGI PEPCCVPEKM SSLSILFFDE NKNVVLKVYP NMTVESCACR
Biological Activity:The ED50 as determined by its ability to inhibit BMP-2-induced activity in murine MC3T3- E1 cells.

Bone Morphogenetic Protein 3 (BMP3) is one of the BMPs, some of which are members of the TGF-beta superfamily (BMP2-7). There are more than 13 BMPs, which are involved in inducing cartilage and bone formation, embryogenesis and morphogenesis of various tissues and organs. In addition, BMPs regulate the growth, differentiation, chemotaxis, and apoptosis of various cell types. Akin to most other TGF-beta family proteins, BMPs are extremely conserved across animal species. At the amino acid sequence level, mature human and rat BMP3 are 98% identical.

BMP3 Human Recombinant produced in E.coli is a non-glycosylated disulfide linked homodimer containing 2 chains of 110 amino acids and having a molecular mass of 24.8kDa.The BMP-3 is purified by proprietary chromatographic techniques.

UniProt Protein Function:BMP3: Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space

Molecular Function:cytokine activity; receptor binding; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; cell development; cell-cell signaling; regulation of apoptosis; regulation of MAPKKK cascade; skeletal development

NCBI Summary:BMP3 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein, also known as osteogenin, induces bone formation. [provided by RefSeq, Jul 2008]
UniProt Code:P12645
NCBI GenInfo Identifier:215273985
NCBI Gene ID:651
NCBI Accession:P12645.2
UniProt Secondary Accession:P12645,Q4VAS5,
UniProt Related Accession:P12645
Molecular Weight:53,372 Da
NCBI Full Name:Bone morphogenetic protein 3
NCBI Synonym Full Names:bone morphogenetic protein 3
NCBI Official Symbol:BMP3��
NCBI Official Synonym Symbols:BMP-3A��
NCBI Protein Information:bone morphogenetic protein 3
UniProt Protein Name:Bone morphogenetic protein 3
UniProt Synonym Protein Names:Bone morphogenetic protein 3A; BMP-3A; Osteogenin
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP3��
UniProt Entry Name:BMP3_HUMAN
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