Cytokines Recombinant Proteins

Human BMP 5 Recombinant Protein (RPPB0099)

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SKU:
RPPB0099
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P22003
Research Area:
Cytokines

Description

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Product Name:Human BMP 5 Recombinant Protein
Product Code:RPPB0099
Size:20µg
Species:Human
Target:BMP 5
Synonyms:Bone morphogenetic protein 5, BMP-5, BMP5, MGC34244.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The BMP-5 solution contains 10mM Sodium Citrate buffer (pH3.5) and 10% Glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MAANKRKNQN RNKSSSHQDS SRMSSVGDYN TSEQKQACKK HELYVSFRDL GWQDWIIAPE GYAAFYCDGE CSFPLNAHMN ATNHAIVQTL VHLMFPDHVP KPCCAPTKLN AISVLYFDDS SNVILKKYRN MVVRSCGCH

BMP5 belongs to the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. This superfamily is comprised of large families of growth and differentiation factors. Bone morphogenetic proteins were initially identified by their ability of demineralizing bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. BMP5 is an essential signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. It was shown that BMP-5 increases the levels of osteopontin, BMP-2, alkaline phosphatase and core binding factor alpha 1 mRNAs in human periodontal (HPL) ligament cells. The BMP5 protein is expressed in normal synovial tissue and reduced in osteoarthritis and rheumatoid arthritis. BMP5 may have a role in certain cancers given that it is differentially regulated during the formation of different tumors.

BMP-5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids (317-454 a.a.) and having a total molecular mass of 15.7 kDa.BMP-5 is purified by proprietary chromatographic techniques.

UniProt Protein Function:BMP5: Induces cartilage and bone formation. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 6p12.1

Cellular Component: extracellular space

Molecular Function:growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: ossification; negative regulation of insulin-like growth factor receptor signaling pathway; pattern specification process; regulation of apoptosis; BMP signaling pathway; negative regulation of cell proliferation; cartilage development; regulation of MAPKKK cascade; negative regulation of aldosterone biosynthetic process; male genitalia development; positive regulation of transcription from RNA polymerase II promoter; skeletal development; positive regulation of epithelial cell proliferation; growth

NCBI Summary:This gene encodes a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. These proteins are synthesized as prepropeptides, cleaved, and then processed into dimeric proteins. This protein may act as an important signaling molecule within the trabecular meshwork and optic nerve head, and may play a potential role in glaucoma pathogenesis. This gene is differentially regulated during the formation of various tumors. [provided by RefSeq, Jul 2008]
UniProt Code:P22003
NCBI GenInfo Identifier:115075
NCBI Gene ID:653
NCBI Accession:P22003.1
UniProt Secondary Accession:P22003,Q9H547, Q9NTM5, B4E0Y4,
UniProt Related Accession:P22003
Molecular Weight:47,670 Da
NCBI Full Name:Bone morphogenetic protein 5
NCBI Synonym Full Names:bone morphogenetic protein 5
NCBI Official Symbol:BMP5��
NCBI Protein Information:bone morphogenetic protein 5; BMP-5; bone morphogenenic protein-5
UniProt Protein Name:Bone morphogenetic protein 5
Protein Family:Bone morphogenetic protein
UniProt Gene Name:BMP5��
UniProt Entry Name:BMP5_HUMAN
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