Neurotrophins Recombinant Proteins
Human Beta-NGF/NGFB Recombinant Protein (RPES3591)
- SKU:
- RPES3591
Description
Human Beta-NGF/NGFB Recombinant Protein
Human beta-Nerve Growth Factor (beta-NGF) was initially isolated in the mouse submandibular gland. It is made up of three non-covalently linked subunits, beta, which has all of the biological effects ascribed to NGF. BDNF is structurally related to it; NT-3 and -4, as well as other cysteine-knot growth factors, are in the family of stable dimeric structures. Beta-NGF is a neurotrophic factor that activates its receptor beta-NGF and has an important function in the formation and maintenance of the sensory and sympathetic nervous systems. Beta-NGF promotes B cell growth and maturation, as well as enhancing B-cell survival. Our findings suggest that beta-NGF is a pleiotropic cytokine, with potential immunomodulatory effects in addition to its neurotrophic effects. The human beta-NGF protein is similar in sequence to mouse protein and exhibits cross-species reactivity. Human Beta-NGF/NGFB Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.
| Product Name: | Human Beta-NGF/NGFB Recombinant Protein (RPES3591) |
| Product Code: | RPES3591 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | E.coli |
| Synonyms: | Beta-Nerve Growth Factor, Beta-NGF, NGF, NGFB |
| Accession: | P01138 |
| Sequence: | Ser122-Ala241 |
| Fusion tag: | |
| Activity: | Measured in a cell proliferation assay using TF?1 human erythroleukemic cells. The ED50 for this effect is 0.03-0.3 ng/ml. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human beta-Nerve Growth Factor is produced by our E.coli expression system and the target gene encoding Ser122-Ala241 is expressed. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 13.4 kDa |
| AP Mol Mass: | 14 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM PB; 250mM NaCl; pH 7.0. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
Additional Information
Product Type: |
Recombinant Protein |
Species: |
Human |
Research Area: |
Neurotrophins |
Related Products
Mouse beta-NGF/NGFB Recombinant Protein (RPES3849)
Mouse beta-NGF/NGFB Recombinant Protein (RPES3871)
Neurotrophins Recombinant Proteins
