Human BCL2L2 Recombinant Protein (RPPB2874)

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SKU:
RPPB2874
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q92843

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human BCL2L2 Recombinant Protein
Product Code:RPPB2874
Size:20µg
Species:Human
Target:BCL2L2
Synonyms:B-Cell Lymphoma Protein 2, BCL2 Like 2, BCL2 Like protein 2, BCLW, Bcl2-L-2, Apoptosis regulator Bcl-W, BCL2L2, BCL-W, KIAA0271.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:BCL2L2 is a 0.2�m filtered concentrated solution which contains 25 mM Hepes, pH 7.4, 100 mM KCl, 10 % Glycerol, 5 % Trehalose, and 0.02 % Tween-80.
Stability:BCL2L2 although stable at room temperature for 3 weeks, should be stored at 4°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Purity:Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE.
Amino Acid Sequence:ATPASAPDTR ALVADFVGYK LRQKGYVCGA GPGEGPAADP LHQAMRAAGD EFETRFRRTF SDLAAQLHVT PGSAQQRFTQ VSDELFQGGP NWGRLVAFFV FGAALCAESV NKEMEPLVGQ VQEWMVAYLE TQLADWIHSS GGWAEFTALY GDGALEEARR LREGNWASVR T

BCL2L2 promotes cell survival. BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. BCL2L2 is part of the BCL-2 protein family which form hetero- or homodimers and play an important role as anti and proapoptotic regulators. BCL2L2 causes reduced cell apoptosis under cytotoxic conditions. BCL2L2 is involved in the survival of NGF- and BDNF-dependent neurons. BCL2L2 plays an important role in adult spermatogenesis.

Recombinant Human BCL2L2 produced in E.coli cells is a non-glycosylated, homodimeric protein containing 171 amino acid chain and having a molecular mass of 18.6kDa. The Human BCL2L2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
NCBI Summary:This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
UniProt Code:Q92843
NCBI GenInfo Identifier:296434404
NCBI Gene ID:599
NCBI Accession:Q92843.2
UniProt Secondary Accession:Q92843,Q2M3U0, Q5U0H4, A8K0F4,
UniProt Related Accession:Q92843
Molecular Weight:37,171 Da
NCBI Full Name:Bcl-2-like protein 2
NCBI Synonym Full Names:BCL2 like 2
NCBI Official Symbol:BCL2L2��
NCBI Official Synonym Symbols:BCLW; BCL-W; PPP1R51; BCL2-L-2��
NCBI Protein Information:bcl-2-like protein 2
UniProt Protein Name:Bcl-2-like protein 2
UniProt Synonym Protein Names:Apoptosis regulator Bcl-W
Protein Family:Bcl-2-like protein
UniProt Gene Name:BCL2L2��
UniProt Entry Name:B2CL2_HUMAN
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