Cell Death Recombinant Proteins

Human BCL-W/BCL2L2 Recombinant Protein (RPES3400)

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SKU:
RPES3400
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Cell Death

Description

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Human BCL-W/BCL2L2 Recombinant Protein

Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a peripheral membrane protein containing three motifs, BH1, BH2 and BH4. The BH4 motif appears to be involved in the anti-apoptotic function. The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. BCL2L2 promotes cell survival and blocks dexamethasone-induced apoptosis. Furthermore, BCL2L2 mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.

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